Pharmacokinetic Research of Xiongbing Nasal Spray in the Brain
- VernacularTitle:芎冰喷雾剂脑内药物动力学研究
- Author:
Hanjing UN
;
Tianlai HUANG
;
Suiqing MI
;
Wei WU
;
Honggu CHEN
- Publication Type:Journal Article
- Keywords:
Xiongbing nasal spray /pharmacokinetics;
Tetramethylpyragine /pharmacokin etics;
Adninistration,in-tranasal;
rats;
Gas chromatography
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
SAbstact:Objective To establish a method for detecting t he pharmacokinetic parameters of te tramethylpyragine(TMPz ),the main active component in Xiongbing nasal spray(A),Chuanxiong nasal spray(B)and Xiongbing decoction(C),in the rat brain .Methods Gas chromatography was applied for pharmacokinetic analysis of TMPz in v arious time after nasal administration or gastr ic infusion.Results The concentration -time process of A can be described in an open two -department model,which is simi lar to the process of intravenous adm inistration.As compared with B and C,A has its characteristics:quick absorpt ion,quick distribution and quick excretion of TMPz.TMPz passed through blood -brain barrier almost right after administration,and reach the peak concentra tion 1minute after the administrati on.95.7%of TMPz was cleared from brain within 1.5h.Conclusion The application of Borneolum makes T MPz of A enter into the rebral tissue easily.Therefore Xiongbing nasal spray is a quick -effective pre paration for acute ischemic stoke an d can be medicated repeatedly.
