Optimizing Alcohol-extraction Process for Fushuning Granules by Orthogonal Design
- VernacularTitle:正交试验法优选妇舒宁颗粒的乙醇提取工艺
- Author:
Ruisong HUANG
;
Kefeng MO
;
Qing SU
;
Aihuan QIN
;
Yin QIN
- Publication Type:Journal Article
- Keywords:
Fushuning Granules /chemistry;
Oleanolic acid /analysis;
TanshinoneⅡ A /analysis;
Orthogonal test;
Pharmaceutical technology(TCD)
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the method and condition s for the extraction process of Fushuning Granules.Methods Different factors and levels were in vestigated by orthogonal design wit h yields of oleanolic acid and tanshi noneⅡ A as the markers.The yields of effective com ponents by percolation and reflux we re compared.Results The extraction ratio by re-flux was higher than that by percolation.The primary factors influencin g extraction ratio by reflux were the pulverization degree of medicinal materials,concentration of alcohol,refluxing times and refluxing perio d.Conclusion The opti-mum extraction process was:refluxing and extracting the pulverized med icinal materials for 3times(1hours each time )with 6-fold 90%alcohol added in the f irst time and then 5-fold in the secon d and the third time.
