Effect of total alkaloids of Equisetum pratense on contents of monoamine neurotransmitters in rat brain
- VernacularTitle:草问荆总生物碱对大鼠脑内单胺类神经递质含量的影响
- Author:
Yubin JI
;
Shiyong GAO
- Publication Type:Journal Article
- Keywords:
total alkaloids of Equistum pratense Ehrh. (TAEP);
CNS inhibition;
monoamine neurotransmitter;
action mechanism
- From:
Chinese Traditional and Herbal Drugs
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To reveal the mechanism of inhibitory action on the central nervous system (CNS) of total alkaloids of Equisetum pratense Ehrh. (TAEP). Methods Contents of monoamine neurotransmitters in brain of rats were determined by HPLC-EC and HPLC-UV. Results TAEP can significantly decrease the contents of monoamine neurotransmitter in the straite body and the bordering area of rat forebrain, increase the contents of neutral and acidic metabolites in the straite body, and increase the contents of 5-HIAA and HVA of the monoamines in the bordering area of rat forebrain. But its raise of DHPG showed no statistical significance. Conclusion TAEP has an evacuating action of monoamine similar to Reserpine. This may be considered as one of the mechanisms of sedative and tranquilizing effect CNS.
