The protective effect of tumor necrosis factor-?antibody on lung injury after cardiopulmonary bypass
- VernacularTitle:体外循环中抗肿瘤坏死因子抗体的肺保护作用
- Author:
Yang YU
;
Shulin JIANG
;
Yanping LIU
- Publication Type:Journal Article
- Keywords:
Heart valve prosthesis implantation Tumor necrosis factor Antibodies Cardiopulmonary bypass Lung injury Lung protection
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the protective effect of anti-tumor necrosis factor-?antibody (TNF-? Ab) on lung injury after cardiopulmonary bypass(CPB). Methods: 20 patients with valve diseases underwent valve replacement under CPB. The patients were randomly divided into two groups: control group and TNF-? Ab group. In the TNF-? Ab group, human TNF-? Ab was dropped into the intracheal tube before operation and just after releasing the aortic clamp, respectively. Lung dynamic compliance, blood neutrophils count and TNF-? from the right and left atrium were determined perioperatively. Results: The dynamic compliance of the lung in TNF-? Ab group was higher than that in control group. TNF-? Ab can reduce releasing of TNF-? and restrain leukocyte accumulation in the lung. Conclusion: TNF-? Ab has markedly protective effect on lung injury after CPB.
