The effect of local mild hypothermia on the cerebral infarction volume,neurologic function and the serum concentration of neuron-specific enolase in rats
- VernacularTitle:局部亚低温对大鼠脑梗死体积和神经功能及血清神经元特异性烯醇化酶的影响
- Author:
Xuzheng CAO
;
Zhiqiang SU
;
Jianmin XU
;
Jie LAN
;
Jichen XING
;
Jun LIANG
- Publication Type:Journal Article
- Keywords:
Mild hypothermia;
Cerebral infarctioin;
Neurologic function;
Neuron-specific enolase
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of local mild hypothermia on the ischemic cerebral tissues. Methods A model of middle cerebral artery occlusion was prepared in Wistar rats to compare the difference of the cerebral infarction volume and neurologic function and the serum concentration of neuron-specific enolase (NSE) between the local mild hypothermia group and the normal temperature group. Results It was found that the cerebral infarction volume was 84.90?11.36 and 128.95?13.42 mm 3 in the local mild hypothermia group and the normal temperature group, the neurologic function score 0.95?0.17 and 1.60?0.24, and the serum concentration of NSE 9.19?3.42 and 13.55?4.07ng/ml,respectively. The differences between the two groups were statistically significant. Conclusion The findings of this study suggest that the local mild hypothermia treatment exerted protective effect on the ischemic neurons.
