The effects of percutaneous coronary interventional therapy on platelet activation and the systemic fibrinolysis in patients with coronary artery disease
- VernacularTitle:冠状动脉介入治疗对血小板活化及纤溶功能的影响
- Author:
De CHEN
;
Erquan HUA
;
Shufu ZHANG
- Publication Type:Journal Article
- Keywords:
Percutaneous coronary;
Interventional therapy;
Alpha granule membrane glycoprotein 140;
Plasminogen activator inhibitor;
D dimer
- From:
Journal of Interventional Radiology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of percutaneous coronary interventional therapy on platelet activation and the systemic fibrinolysis in patients with coronary artery disease (CAD).Methods The plasma concentration of platelet alpha granule membrane glycoprotein 140 (GMP 140), plasminogen activator inhibitor 1(PAI 1), tissue type plasminogen activator (t PA), von Willebrand factor (vWF) and D dimer (D D) of the blood sampled from vein according to the schedule were measured by ELISA. Results In the sixty five patients with CAD, at 10 minutes after the procedure, plasma levels of GMP 140, t PA and D D were significantly higher than the previous ones; and at 24 h, plasma levels of PAI 1 and vWF were also increased significantly. Conclusions The activation of platelet and impaired fibrinolytic activity were occurred after PCI in the patients with CAD.
