Shear stress-regulated vascular endothelial permeability is mediated by Rho GTPases
10.3760/cma.j.issn.1673-4181.2009.03.009
- VernacularTitle:Rho GTP酶介导剪切力引起的血管内皮细胞通透性变化
- Author:
Ting GAO
;
Longjuan XUE
;
Xiaoheng LIU
- Publication Type:Journal Article
- Keywords:
Shear stress;
Rho GTPases;
Vascular endothelial cells;
Permeability
- From:
International Journal of Biomedical Engineering
2009;32(3):162-165,176
- CountryChina
- Language:Chinese
-
Abstract:
Dysfunctions of vascular endothelial permeability are related to a number of human diseases such as atherosclerosis, high blood pressure, stroke, inflammation, cancer, diabetes-induced retinopathy, macular edema and so on. Shear stress is an important mechanical force that affects vascular endothelial cells. It plays a particular role in permeability regulation. Rho GTPases is a family of small G proteins which act as cell signal molecules. They are assumed to mediate the regulation of the permeability of vascular endothelial cells. In this paper review is given on how shear stress regulates the permeability of vascular endothehal cells as well as the in-fluence of Rho GTPases on the role in molecular mechanism. It is suggested that shear stress-regulated vascular endothelial permeability is mediated by Rho GTPases.
