Pharmacodynamic Studies on Matrine Eye Drops for Experimental Ocular Inflammation in Rabbits
- VernacularTitle:苦参碱滴眼液对家兔实验性眼炎的药效学研究
- Author:
Maqing ZHENG
;
Weina PAN
;
Yanqin ZHU
- Publication Type:Journal Article
- Keywords:
Matrine/pharmacology;
Experimental ocular inflammation/TCD therapy
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effects of matrine eye drops (MED) on experimental ocular inflammation in rabbits. Methods The effects of 0. 5 % and 1.0% MED, dexamethasone eye drops, saline solution were e-valuated in the rabbits with ocular inflammation induced by paracentesis of anterior chamber and capsicum tincture respectively. Results MED could significantly inhibited the increase of protein concentration in aqueous humor induced by anterior chamber paracentesis, and the anti - inflammatory effect of MED on capsicum - tincture - induced extra ocular and intraocular inflammation was similar to dexamethasone eye drops. There were no significant difference between 1.0% MED and dexamethasone eye drops. Conclusion MED has a good effect on experimental ocular inflammation in rabbits.
