Effect of total alkaloids of Equisetum pratense on amino acid neurotransmitters and Ach of striatum in rat brain
- VernacularTitle:草问荆总生物碱对大鼠脑内氨基酸类神经递质含量和纹状体内乙酰胆碱含量的影响
- Author:
Yubin JI
;
Shiyong GAO
- Publication Type:Journal Article
- Keywords:
total alkaloids of Equisetum pratense Ehrh. (TAEP);
amino acid neurotransmitters;
Ach
- From:
Chinese Traditional and Herbal Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the effect of total alkaloids of Equisetum pratense Ehrh. (TAEP) on the contents of amino acid neurotransmitters and Ach in rat brain to reveal the mechanism of TAEP inhibitory action on the central nervous system (CNS). Methods Contents of amino acid neurotransmitters and Ach in rat brain were determined by double-wavelengh scan and GPI mensuration. Results TAEP could not influence four kinds of content of amino acid neurotransmitter (glutamic acid, glycin, ?-aminobutyric acid, aspartic acid), but TAEP could significantly lower the content of Ach in striatum of rat. Conclusion The inhibition of TAEP to CNS is attained by lowering the content of Ach in striatum to affect DA-2 receptor, and it is irrelevant to the amino acid neurotransmitters (glutamic acid, glycin, ?-aminobutyric acid, aspartic acid).
