Effects of mild hypothermia on heart of rats with focal brain ischemia
- VernacularTitle:亚低温治疗实验性脑梗死时对心脏的影响
- Author:
Chengyan LI
;
Tao LI
;
Xiaofeng GAO
;
Shaozu YU
- Publication Type:Journal Article
- Keywords:
Mild hypothermia;
Focal brain ischemia;
Myocardial high-energy phosphate;
Myocardial ultrastructure
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of systemic mild hypothermia on heart. Methods Fifty-eight Wistar rats were divided randomly into three groups: control group (n=10), normal thermic group (n=24) and mild hypothermic group (n=24). After the model of middle cerebral artery occlusion (MCAO) was made, electrocardiograph (ECG) was used to monitor the cardiac function of the animals. The changes of myocardial high-energy phosphates (ATP,ADP,AMP) and energy charge (EC) were evaluated after 12 hours of ischemia, and the myocardial ultrastructure observed. Results Compared with the control group, the ATP, ADP and EC in the normal thermic group and mild hypothermic group were lower after 12 hours of ischemia (P
