Study on the expression of the gene deleted in colorectal carcinoma in ovarian carcinoma
- VernacularTitle:DCC基因在卵巢恶性肿瘤组织中的表达
- Author:
Peiling LI
;
Meimei LIU
;
Jiang NI
- Publication Type:Journal Article
- Keywords:
Gene,DCC;
Ovarian neoplasms;
Gene expression
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to explore the relationship between the loss of the gene deleted in colorectal carcinoma (DCC) gene expression in ovarian carcinoma and the transformation, progression of the tumor and its clinicopathological factors. Methods DCC gene mRNA expression were examined by reverse transcription polymerase chain reaction (RT-PCR) in 34 malignant, 10 benign and 10 normal ovarian samples. To clarify the expression of DCC gene by the DNA cloning and the DNA sequencing analysis in normal ovarian sample. Results The expression of DCC gene was lost in no normal ovarian tissues, in 2 (2/10) benign lesions, while the loss of DCC gene expression was found in 19(19/34,56%) carcinomas ( P
