Myocardial protection of induction and reperfusion with warm blood cardioplegia in hypoxic neonatal rabbits
- VernacularTitle:温血诱停及再灌注对缺氧未成熟心肌保护的实验研究
- Author:
Bin LAN
;
Xi ZHANG
;
Muquan LI
- Publication Type:Journal Article
- Keywords:
Anoxia Heart arrest, induced Myocardial reperfusioninjury Animal testing alternatives
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2003;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the myocardial protection of induction and reperfusion with warm blood cardioplegia for hypoxic immature myocardium. Methods: A hypoxic model of neonatal rabbits was established in this study. Some indexes,such as myocardial energy metabolism, water content, SOD, MDA and myocardial ultrastucture, were observed after induction and reperfusion with warm blood cardioplegia, comparing to cold crystalloid cardioplegia. Results: Hypoxic neonatal rabbits in this study presented cyanotis, hypoxemia and higher ratio of RV/(LV+S) simulating the pathophysiological changes in cyanotic congenital heart disease. It could be built and repeated easily in experimental researches of immature myocardial protection. Myocardial ATP content was (13.09?1.50) ?mol/g in studying group versus (11.53?5.40)?mol/g in control group (P
