Effects of Tongbiling Prescription in Counteracting Cartilage Destruction in Rats with Collagen-induced Arthritis
- VernacularTitle:通痹灵对胶原诱导性关节炎大鼠软骨破坏的对抗作用
- Author:
Jifan CHEN
;
Liuzhong YE
;
Guangxing CHEN
;
Xiaojuan LI
;
Qingping LIU
;
Qingchun HUANG
- Publication Type:Journal Article
- Keywords:
ARTHRITIS, RHEUMATOID/TCD therapy;
TONGBILING/phannacology;
GUIZHI SHAOYAO ZHIMU DECOCTION/pharmacology;
CARTILAGE, ARTICULAR/drug effects;
TUMOR NECROSIS FACTOR;
TRANSFORMING GROWTH FACTOR BETA
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the effects of Tongbiling (TBL) prescription in counteracting cartilage destruction in rats with rheumatoid arthritis (RA). [Methods] Collagen-induced arthritis (CIA) rat models were established to observe the therapeutic effects of TBL. After a short-term treatment, expressions of tumor necrosis factor (TNF - a) and transforming growth factor (TGF- P) in cartilage tissue of model group, methotrenxate (MTX) tablets group and Radix Tripterygii Wilfordii (RTW) preparation group were examined by immunohistochemical semi-quantitative assessment method. [ Results ] The number of chondrocytes with positive TNF - a expression was lower and the chondrocytes were stained lighter in normal group than those in model group and low-dose MTX group ( P
