Genetic research progress of bicuspid aortic valve and it's clinical significance
10.3760/cma.j.issn.1673-4408.2010.02.013
- VernacularTitle:二叶式主动脉瓣的遗传学研究进展及其临床意义
- Author:
Wu ZHAO
;
Fen LI
- Publication Type:Journal Article
- Keywords:
Bicuspid aortic valve;
Gene mutation
- From:
International Journal of Pediatrics
2010;37(2):149-151,154
- CountryChina
- Language:Chinese
-
Abstract:
Bicuspid aortic valve(BAV) is one of the most common congenital cardiovascular malformations,affecting 1% to 2% of the population.BAV may be sporadic or familial.BAV is likely a multiple genetic disorder based on the study of heritability and identification of pathogenic genes and potential candidate genes.With increasing studies of related genes of BAV,early intervention and gene therapy of BAV and associated complications may be likely in the near future.
