Effects of Qibao Meiran Pellet on Free Radicals and Immune Indexes in Aging Rats
- VernacularTitle:七宝美髯丹对衰老大鼠自由基及免疫指标的影响
- Author:
Chengzhe LI
;
Changchun ZENG
;
Jinping LI
;
Baoliang LI
- Publication Type:Journal Article
- Keywords:
AGING/drug effects;
QIBAO MEIRAN PELLET/phaimacology;
QIBAO MEIRAN PELLET/immunology;
MALONDIALDEHYDE/blood;
SUPEROXIDE DISMUTASE/blood;
REINFORCING KIDNEY;
ACTIVATING BLOOD
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the anti - aging effects and explore the mechanism of Qibao Meiran Pellet (QMP) and its modified prescriptions, including QMP with qi - invigorating and spleen - strengthening herbs, with kidney -nourishing herbs or with blood - activating and purgative herbs. [ Methods ] Ten - month - old model rats were established by D - galactose. Serum free radical levels and immune indexes in QMP group and various modified QMP groups were observed. [ Results ] QMP increased the activity of superoxide dismutase ( SOD). QMP combined with kidney - nourishing herbs or blood - activating and purgative herbs decreased the serum level of malondialdehyde (MDA) and increased the activities of glutathione peroxidase (GSH - Px) and SOD. Meanwhile, QMP combined with kidney -nourishing herbs increased interleukin - 2 activities. [ ConclusionJ QMP, mainly composed of herbs for nourishing liver and spleen, can delay the aging of rats, and spleen - strengthening herbs and blood - activating and purgative herbs also play an important role in the delay of aging. Furthermore, it is suggested that the anti - aging effect of herbal medicine is related to the sex.
