Experimental study on effect of apoptosis of K562 cells treated with TSPG
- VernacularTitle:人参总皂苷诱导K562细胞凋亡的实验研究
- Author:
Tingmei CHEN
;
Yaping WANG
;
Dilong CHEN
;
Jing LI
- Publication Type:Journal Article
- Keywords:
total saponins of Panax ginseng C. A. Mey (TSPG);
K562 cells;
apoptosis
- From:
Chinese Traditional and Herbal Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To clarify the mechanism for total saponins of Panax ginseng C.A.Mey. (TSPG) inducing K562 cells to apoptosis, and to provide the theoretical basis and the experimental evidence of TSPG's clinical application. Methods By using in vitro cell culture, morphometry, flow cytometry, morphological investigation and immunocytochemistry, the effects of TSPG on apoptosis in K562 cells were studied. Results The results indicated that TSPG could inhibit the proliferation of K562 cells significantly, and induce K562 cells to apoptosis. It was also showed in the experiments that after induced by TSPG, the ratio of positive K562 cells expressing C-MYC and BCL-2 is decreased. Conclusion The mechanism for TSPG to induce K562 cells to apoptosis may be related to the expression of oncogene in K562 cells.
