Effects of coumarin from LEG on contractivity in isolated rabbit ileum
- VernacularTitle:东北鹤虱中香豆素类对兔离体回肠的作用
- Author:
Lin MENG
;
Yongqiang YIN
;
Jianhua GAO
;
Jing ZHOU
- Publication Type:Journal Article
- Keywords:
Lappula echinata Gilib (LEG);
coumarin (CM);
Verapamil (Ver);
ileal smooth muscle
- From:
Chinese Traditional and Herbal Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To observe the effects of coumarin (CM) and Verapamil (Ver) on contractivity and its relationship with Ca 2+ in isolated ileal smooth muscle of the rabbits. Methods The effects of CM and Ver were observed in three doses by routine experimental methods in isolated rabbit ileal. Results CM and Ver inhibited the contraction of isolated ileal smooth muscle induced by acetylcholine and CaCl 2. The responses were a concentration-dependent and non-competitive manner. CM and Ver were effective against the initial and sustained peak induced by acetylcholine. Conclusion CM has a calcium-antagonistic effect which is similar to that of Ver.
