Expression and significe of Survivin in breast carcinoma
- VernacularTitle:Survivin在乳腺癌中的表达及临床意义
- Author:
Lixin HUA
;
Guilin HUANG
;
Yujiang LI
- Publication Type:Journal Article
- Keywords:
breast carcinoma;
Survivin;
immunohistochemistry;
follow-up prognosis
- From:
International Journal of Surgery
2008;35(5):311-314,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of Survivin in breast carcinoma combined with prognosis of ten-year follow-up.Methods The expression of Survivin was investigated by immunohistochemistry in 60 cases of breast cancer and 20 tumor surrounding tissue.All the cases were performed with prognosis of tenyear follow-up.Results The expression rate of Survivin in breast carcinoma(68.3%)was higher than that in fibroadenoma of bast tissue(25%)(χ2=20.03,P＜0.01).Survivin didn't experss in tumor surrounding tissue.There Was no relationship among the expression of Survivin and the histological differentiation,clinical staging,and lymph node metastasis of breast carcinoma.The expression of Survivin was correlated with the survival years of patients.Conclusion The expression of Survivin was up-regulated in breast carcinoma,which indicated that survivin may play an important role of the genesis and development of breast cancer,but it may play negative correlated with breast carcinoma.
