Association of CA repeats polymorphism in the promoter region of IGF-1 gene with metabolic syndrome
10.3760/cma.j.issn.1008-1372.2011.02.016
- VernacularTitle:IGF-1基因启动子区CA重复序列多态性与代谢综合征关系研究
- Author:
Min YANG
;
Hongding XIANG
;
Wei CHEN
;
Wei LING
- Publication Type:Journal Article
- Keywords:
Insulin-like growth factor I/GE;
Polymorphism,genetic;
Promoter regions (genetics);
Metabolic syndrome X/GE
- From:
Journal of Chinese Physician
2011;13(2):197-199,202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between CA repeats polymorphism in the promoter region of IGF-1 gene and MS in the Han nationality.Methods 1047 subjects were recruited from general population of Dongcheng District in Beijing.MS was diagnosed based on the criteria for MS in 2005 by IDF.Genomic DNA was extracted by standard methods.PCR,Genescan,Genotyper and direct sequencing were conducted to screen CA repeats polymorphism in the promoter region of the human IGF-1 gene.Levels of plasma glucose,lipids,serum insulin and IGF-1 were determined.BMI and ISI were calculated.Results The prevalence of MS in (CA) 19 homozygote was lower than that in (CA) 19 heterozygote (9.1% vs 18.3%,x2 = 8.55,P ＜ 0.01) and without (CA) 19 (9.1% vs 24.0%,x2 = 18.05,P ＜ 0.01).The level of serum IGF-1 had differences among the three groups [ (114.0 ± 52.6) μg/L vs (136.6 ± 80.5) μg/L vs (129.2±49.1) μg/L,F =3.16,P ＜0.05],(CA)19 homozygote had lower serum IGF-1 than (CA)19heterozygote and without (CA) 19.BMI,WC,TG,FIns,2hIns and ISI had difference among the three groups (P ＜0.05).Conclusions (CA)19 repeats polymorphism in the promoter region of IGF-1 gene was significantly associated with MS in Han nationality.
