Effect of Buxu Huayu Prescription on Myeloid Hematopoiesis in Tumor -bea ring Mice After Combined Chemotherapy
- VernacularTitle:补虚化瘀方对联合化疗荷瘤小鼠骨髓造血功能的影响
- Author:
Weiwei TIAN
;
Ou LI
;
Yinghong HUANG
;
Daochang DENG
;
Qingmia WANG
- Publication Type:Journal Article
- Keywords:
Buxu Huayu Prescription /pharmacology;
Cytarabine /adverse effects;
Cyclo phosphamide /adverse ef-fects;
Arrest of bone marrow /TCD therapy;
Disease models,animal
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Buxu Huayu P rescription(BHP)on myeloid hematopoiesis in tumor -b ear-ing mice after combined chemotherap y.Methods Tumor -bearing mouse models were established by implanting P388tu-mor strain and the arrest of myeloid h ematopoiesis in the models was induced by intraperitoneal injection of c yclophos-phamide(CTX)and cytarabine(Ara -c ).The mice were allocated to 3groups:the normal control group,the model group and BHP group.Peripheral bloo d cell count,bone marrow karyocytes(BMK)count,colony count of progenitors o f granulocytes /monocytes(CCP -GM)and the proliferation of bone marrow cells(BMC)were examined.Results The combination of CTX and Ara -c could decrease plasma hemoglobin(Hb )content,the number of white blood cells(WBC),BMK and CCP -GM and the proliferatio n of BMC in model mice(P
