Effect of Active Components of Zhi Ga ncao Decoction and Their Combinatio n on Triggered Activity and Myocar-dial Damage in Isolated Ischemia -reperfusion Rat Heart
- VernacularTitle:炙甘草汤有效成分及其配伍对缺血再灌离体大鼠心脏触发活动及心肌损伤的影响
- Author:
Xinggao LI
;
Qi CHEN
;
Mengyu HUANG
;
Ming BI
;
Lanyin CHEN
- Publication Type:Journal Article
- Keywords:
Zhi Gancao Decoction /pharmacology;
Heart /drug effects;
Heart /physiopathology;
Myocardial reperfusion injury /physiopathology
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of active components(glycyrrhizic acid monoaminate,total ginsenoside and to-tal ophiopogonoside)of Zhi Gancao Decoction(ZGD)and their combination on the triggered activity and myocardial dam-age in the isolated ischemia -reperfusion rat heart.Methods Isolated rat heart was treated with L angendroff perfusion and monophase action potential technology was applied.Results &Conclusion Total extract of ZGD,single active c omponents and their combination can markedly l ower the incidence of cardiac triggered activity,prevent the myocardiu m from injury and decrease the incidence of arrhythmia induced by ischemia -reperfusion in rats and the effects of their com bination are positively related to the doses.
