PERIPHERAL IMMUNE CHALLENGE-INDUCED CHANGES OF THE IL-1 RECEPTOR TYPEⅠEXPRESSION IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS AND SUPRAOPTIC NUCLEUS IN MICE
- VernacularTitle:外周免疫刺激诱导小鼠下丘脑室旁核和视上核中Ⅰ型IL -1受体表达的变化
- Author:
Gaili LI
;
Bairen WANG
;
Gong JU
- Publication Type:Journal Article
- Keywords:
Neuroimmunomodulation;
IL\|1 receptor type Ⅰ;
Paraventricular nuclei of the hypothalamus;
Supraoptic nuclei;
Immunohistochemistry;
Mouse
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the role of hypothalamic neuroendocrine nuclei in neuroimmunomodulation,peripheral immune challenge\|linduced changes of immune cytokine receptor expression in hypothalamic paraventricular nucleus(PVN) and supraotic nucleus(SON) were studied. Methods Following LPS or SEB was administered intraperitoneally,the expression of proliferating cell nuclear antigen(PCNA) of splenic cells and IL\|1 receptor type Ⅰ in PVN and SON were observed by using immunocytochemistry.Double fluorescent labeling technique was used to determine the relationship of IL\|1 receptor type Ⅰ co\|expressions with arginine vasopressin or oxytocin. Results 1.Compared with the controls,the expression of PCNA of mouse splenic cells was significantly enhanced by LPS or SEB ( P
