Establishment of a rat model of gut hypersensitivity and for evaluation of visceral sensitivity
- VernacularTitle:大鼠肠道高敏性模型的建立及其内脏敏感性评估
- Author:
Yanbing LIU
;
Yaozong YUAN
;
Ranjun TAO
- Publication Type:Journal Article
- Keywords:
Irritable bowel syndrome;
Visceral hypersensitivity;
Irritation intrarectally;
Rectal distension;
Abdominal electrical activity
- From:
Chinese Journal of Digestion
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Visceral hypersensitivity is an important feature of irritable bowel syndrome (IBS). This investigation was to establish an animal model of visceral hypersensitivity associated with IBS, and to test its effectiveness by two different ways. Methods The model was established by intrarectal administration of acetic acid daily in the neonatal rats between postnatal 8 and 21 days. The threshold of abdominal withdrawal reflex(AWR) was evaluated during rectal distension at postnatal 6,8 and 10 weeks respectively, and the changes of rectal sensitivity were identified by the abdominal electrical activity measured at postnatal 12 weeks. Results In contrast to neonatal rats subjected to saline intrarectally (NS group) and adult rats subjected to acetic acid intrarectally (AA group), neonatal rats subjected to acetic acid intrarectally(NA group) showed a significant decrease(P
