Protective Effect of Swertia Punicea on Experimental Hepatic Injury
- VernacularTitle:紫红獐牙菜对实验性肝损伤的保护作用
- Author:
Fang PENG
;
Xiaobao LIU
;
Chunsheng FANG
;
Zaikang YANG
;
Huaming ZHANG
- Publication Type:Journal Article
- Keywords:
Swertia Punicea/pharmacology;
@hepatic injury/TCD therapy
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: to observe the protective effect of Swertia Punicea on experimental hepatic injury induced by CCl4 and BCG/LPS respectively. Methods: Mouse models of hepatic injury were induced by CCl4 and BCG/LPS. Serum levels of ALT and AST, MDA content and the pathological changes of hepatic tissue were observed. Results: Swertia Punicea obviously inhibited the rising levels of serum ALT and AST, improved the histological features and relieved hepatic edema induced by CCl4 in mice. However, it has no obvious action on the rising levels of ALT and AST induced by BCG/LPS. It also reduced MDA content and decreased the hepatic index and the splenic index. Conclusion: Swertia Punicea has antioxidation and a protective action on the chemical and immunological hepatic injury, especially on the chemical hepatic injury.
