The susceptibility of Plasmodium falciparum to pyrimethamine and cycloguanil in a malarial area of Quang Binh
- Author:
Le Ngoc Anh
- Publication Type:Journal Article
- Keywords:
plasmodium falciparum, pyrimethamine, cycloguanil, malarial
- MeSH:
Plasmodium falciparum;
Pyrimethamine;
Chloroguanide;
malaria
- From:Journal of Preventive Medicine
2004;14(6):48-53
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
PCR-RFLP and DNA sequencing techniques were used for Pyrimethamine (PYR) and Cycloguanil (CYC) resistant mutations. The study results showed that 46 of 58 Plasmodium falciparum isolates were genotype resistant to pyrimethamine (79.31%). Thirty-one isolates were taken in vitro microscopic examination and revealed that 26 of 31 isolates were PYR resistance (83.87%) and 6 of 31 isolates of CYC resistance (19.35%). The resistant levels of these isolates were related to the mutations in DHFR genes
