Effects of BUSHEN YIZHI DECOCTION on interspace explore learning and memory in rat model with Alzheimer's disease
- VernacularTitle:补肾益智方对老年性痴呆模型动物空间探索学习记忆功能的改善作用
- Author:
Kuihua ZHANG
;
Shilong LAI
;
Qi WANG
;
Shuyi CHENG
;
Yunb CHEN
- Publication Type:Journal Article
- Keywords:
BUSHEN YIZHI DECOCTION (BSYZD);
Alzheimer's disease;
learning and memory function;
interspace explore
- From:
Chinese Traditional and Herbal Drugs
1994;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To observe the improving effects of BUSHEN YIZHI DECOCTION (BSYZD) on interspace explore learning and memory in rat model with Alzheimer's disease. Methods Eighty 15-month Wistar rats were induced by ip D -galactose for four weeks and injection of basal nucleus of Meynert with ibotenic acid (IBO) to make AD model, then randomly divided into AD model group, Hup-A treated group, BSYZD (high dose, 12 g/kg?d) treated group and BSYZD (low dose, 6 g/kg?d) treated group, and also normal aged and young groups. After treating for four weeks, Morris water maze was used to assess the improvement of rat interspace explore learning and memory. Results In the interspace explore experiment, the significant differences were observed between the model, Hup-A treated groups and normal aged, young groups (P0.05). Conclusion BSYZD possesses a certain preventive effects on interspace explore learning and memory in AD rat model.
