Association of SNPs within IL-10 promoter region with childhood systemic lupus erythematosus
- VernacularTitle:白细胞介素-10启动子区单核苷酸多态性与少儿系统性红斑狼疮相关性研究
- Author:
Yanliang JIN
;
Nan SHEN
;
Yueying GU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Nucleotides;
Polymorphism;
Promoter region;
Interleukin 10;
Adolescence
- From:
Chinese Journal of Rheumatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between three SNPs of IL 10 promoter and childhood systemic lupus erythematosus (SLE).Methods Three SNPs( 1082/ 819/ 592) were genotypes,and evidence for linkage disequilibrium was analyzed using Genehunter 2 0 software.The correlations between symptoms and haplotypes were assessed.Results The results showed that all genotypes and haplotypes in the IL 10 promoter region exhibited to significant association with childhood SLE,and no significant differences in clinical features among childhood SLE with various haplotypes could be demonstrated.But the frequence of haplotype GCC ( 1082 *G 819 *C 592 *C) in children with SLE and their parents was higher than that in adult SLE patients and adult normal controls,and the frequence of ATA in children with SLE was lower than that of adult SLE patients.Conclusion It is concluded that haplotype GCC might have certain relationship with childhood SLE,which deserves further study.
