EFFECTS OF RGD-POLYPEPTIDE(224) ECHISTATIN AND 17?-ESTRODIOL ON OSTEOCLASTIC BONE RESORPTION ACTIVITIES
- VernacularTitle:RGD多肽(224)、蛇毒和17?-雌二醇对破骨样细胞骨吸收活性的影响
- Author:
Yan XUE
;
Hui TAN
;
Youbo CAI
;
Feng YU
;
Jianguo TANG
;
Jian JING
- Publication Type:Journal Article
- Keywords:
RGD\|polypeptide (224);
Bone resorption;
Osteoclast like cell
- From:
Acta Anatomica Sinica
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study is to understand the effects of RGD\|peptide(224), Echistatin and 17 ? estrodiol on bone resorption. Methods RGD\|polypeptide (224) (RGD), Echistatin(Ech) and 17 ? estrodiol (E\-2) were added into osteoclast like cells (OLC) and ivory bone slices co\|cultured system. Results It has been found that 10 -7 mol/L RGD, Ech and E\-2 decreased the number of resorption lacunae, resorption area and resorption cave on bone slices in various degrees.Conclusion RGD, Ech and E\-2 inhibits the bone resorption activities in various degrees. [
