Mast cell and substance P-positive fibers of ileocecal junction in irritable bowel syndrome patients
- VernacularTitle:肠易激综合征肥大细胞与P物质免疫反应阳性神经纤维的实验研究
- Author:
Wenzhu DONG
;
Zhaoshen LI
;
Guoming XU
- Publication Type:Journal Article
- Keywords:
Irritable bowel syndrome;
Mast cell;
Substance P positive fibers
- From:
Chinese Journal of Digestion
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether there are changes of the mast cell(MCs) and substance P(SP) positive fibers in ileocecal junction(ICJ), and to elucidate their possible roles in the pathogenesis of irritable bowel syndrom(IBS). Methods The biopsies of the ICJ were stained specifically with histochemistry for the MCs in 31 patients with IBS and 20 controls, and the expression of SP positive fibers was analyzed by immunohistochemistry. The results were investigated qualitatively and quantitatively by means of immunohistochemical methods and color image analyzer. The structure relationship between MCs and nerves was studied through electronic microscopy. Results The number of the MCs of ICJ was significantly elevated in the IBS ( P
