The dissolution test for dermal applied preparations of aciclovir in vitro
- VernacularTitle:阿昔洛韦外用制剂的溶出度试验
- Author:
Yun CHEN
;
Feng SHAO
;
Chongpu ZHANG
- Publication Type:Journal Article
- Keywords:
aciclovior;
dissolution test;
gel;
cream;
ointment
- From:
Chinese Pharmaceutical Journal
1998;(4):237-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the dissolution amounts of aciclovir (ACV) from differently based preparations and provide the evidence for the development of new preparation of ACV. METHOD: The dissolution tester was applied for the quantitative determination of ACV released from 3 based formulations and 5 concentrations samples. The release amount per unit area (M) and the accumulative release percentage (Q) were compared respectively. RESULTS: The value for M was raised with the increase of the concentration of aciclovir in preparations, and for Q was reduced. The release rates of the aciclovir gel were at least two times faster than the creams and the ointment. CONCLUSION: The drug dissolution from ACV gel was better than the creams and the ointment. 10 gkg-1 ACV in prearation was the suitable concentration.
