Relationship of vascular endothelial growth factor with bile acid in intrahepatic cholestasis of pregnancy
- VernacularTitle:妊娠肝内胆汁淤积症患者高水平胆汁酸对血管内皮细胞生长因子的作用
- Author:
Songyun XIA
;
Zhuqin CHEN
;
Li LI
- Publication Type:Journal Article
- Keywords:
Pregnancy complications;
Cholestasis intrahepatic;
Endothelial growth factors;
Glycocholic acid;
Fetal distress
- From:Chinese Journal of Obstetrics and Gynecology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of vascular endothelial growth factor (VEGF) with bile acid in intrahepatic cholestasis of pregnancy patients (ICP). Methods Thirty three ICP patients and 30 normal pregnant women in late pregnancy were studied, maternal serum VEGF concentrations were examined by enzymelinked immunoadsorbent assay (ELISA). Capillaries density in placenta are detected by s ABC immunohistochemistry, radio immunity method is used to assay the maternal serum glycocholic acid. Results Serum VEGF in ICP (2 072? 17) ng/L has negative correlation with glycocholic acid (47 9?14 2) ng/L, however, positive correlation with capillaries density in placenta (68?5)/HP; The serum VEGF in normal pregnant woman (2 256?30) ng/L does not have relationship to glycocholic acid (1 6?0 7) ng/L but it has positive correlation with capillaries density in placenta (74?7)/HP.Conclusion Cytotoxicity of high concentration bile acids impairs vascular endothelial cells resulting in lower excretion of VEGF in vascular endothelial cells of ICP, which lead to placental blood capillaries dysplasia and lower permeability, it may be one of reasons of fetal distress and fetal death in uteri in ICP.
