Assessment on the accuracy of diagnostic methods for Helicobacter pylori infection in patients with partial gastrectomy
- VernacularTitle:胃大部切除术后患者幽门螺杆菌感染诊断方法的评估
- Author:
Xiaobo LI
;
Wenzhong LIU
;
Zhizheng GE
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
14 C urease breath test;
Rapid urease test;
Partial gastric resection
- From:
Chinese Journal of Digestion
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the status of Helicobacter pylori(H.pylori) infection and the accuracy of the two commonly used diagnostic methods, the 14 C urease breath test( 14 C UBT) and the rapid urease test(RUT) in patients with partial gastrectomy due to peptic ulcer or gastric cancer. Methods Culture, histology, RUT, combined with 14 C UBT, were carried out to diagnose the H. pylori infection in patients with partial gastrectomy. The Giemsa staining and H.pylori culture served as the ‘golden reference’ in evaluating the diagnostic accuracy of the RUT and 14 C UBT. The prevalence of H.pylori infection of patients with partial gastrectomy was determined with the dyspeptic controls without surgery. Results 37 patients (17 Billroth Ⅰ resection, 20 Billroth Ⅱ resection) were included in the study. The overall prevalence in the Giemsa staining and culture proved as H.pylori infection was 29.7%, and no statistical difference was seen between patients will Billroth Ⅰ(29.4%) and Billroth Ⅱ(30.0%) resections. The sensitivity of the RUT was 72.7%, the specificity was 57.7%, and the overall accuracy was 62.2%. The sensitivity of the 14 C UBT was 63.6%, the specificity was 100.0%. The negative predictive value was 86.7%, and the overall accuracy was 89.2%. The total prevalence of H.pylori infection in the controls was 71.4%. Conclusion Prevalence of H.pylori infection in patients with partial gastric resection is low. The two diagnostic methods, 14 C UBT and RUT, cannot be recommended as accurate diagnostic tools for H.pylori infection in patients after partial gastrectomy due to low specificity and low sensitivity, respectively.
