Effect of Plastrum Testudinis on Three Subtypes of NOS Expression in Rats with Focal Cerebral Ischemia
- VernacularTitle:龟板对大鼠局灶性脑缺血模型3种NOS亚型的作用
- Author:
Dongfeng CHEN
;
Shaohui DU
;
Yiwei LI
;
Jin ZHANG
;
Hui LI
- Publication Type:Journal Article
- Keywords:
Carapax et plastrum testudinis/pharmacology;
@Focal cerebral ischemia/TCD therapy;
@nNOS/analysis;
@iNOS/analysis;
@eNOS/analysis;
Disease models, animal
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of Plastrum Testudinis on the three subtypes of NOS (nNOS,iNOS,eNOS) expression in rats with focal cerebral ischemia. Methods:Rat model of focal cerebral ischemia was set up by inserting nylon thread into the internal carotid artery . The expressions of nNOS, iNOS and eNOS was detected by immunohistochemical method to observe the effects of Plastrum Testudinis. Results: Expressions of nNOS and iNOS in cerebral cortex and caudate-putamen of Plastrum Testudinis treatment group were significantly lower than those of model control group (P
