Comparison Between Borneol-induced Opening of Blood-brain Barrier and Its Pathological Opening
- VernacularTitle:冰片促血脑屏障开放与病理性开放的比较
- Author:
Baosheng ZHAO
;
Qide LIU
- Publication Type:Journal Article
- Keywords:
Borneol/ pharmacology;
Blood-brain barrier/drug effects;
@Inducible nitric oxide synthetase /analysis
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the difference between borneol-induced opening of blood-brain barrier (BBB) and its pathological opening . Methods: The expression of inducible nitric oxide synthetase (iNOS) in brain microvascular endothelial cells in normal rats and brain-injury rats before and after treatment of borneol was examined by immunohistochemical methods with S-P staining and iNOS antibody. Results: iNOS expression was not different in normal rats before and after treatment. However, iNOS expression was increased in brain-injury rats and borneol could inhibit the expression of iNOS. Conclusion: Borneol-induced opening of BBB is different from pathological opening of BBB. Borneol can increase the pathological opening of BBB and has a protective effect on brain tissue.
