Expression of matrix metalloproteinase-2,9 and it′s tissue inhibitor-1,2 in endometrial carcinoma
- VernacularTitle:基质金属蛋白酶及其组织抑制因子在子宫内膜癌中的表达及其意义
- Author:
Wenping GUO
;
Guian CHEN
;
Cheng ZHU
;
Hongmei WANG
- Publication Type:Journal Article
- Keywords:
Endometrial neoplasms;
Stromelysin 1;
Tissue inhibitor of-metalloproteinases-3
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of matrix metalloproteinase(MMP)-2,9 and tissue inhibitor of metalloproteinase(TIMP)-1,2 protein in human endometrial carcinoma tissue and its relation to the invasion and metastasis of endometrial carcinoma. Methods Immunocytochemistry and zymography techniques were used to measure the MMP-2,MMP-9,TIMP-1,TIMP-2 protein levels and activities in endometrial carcinoma tissue of 37 patients and control group composed of 7 normal postmenstrual endometrial samples. Results The MMP-2,MMP-9,TIMP-1 and TIMP-2 proteins mainly expressed in endometrial carcinoma cells, glandular cells and endothelial cells. The strongly positive expression proportions of MMP-2,9 and TIMP-1 proteins in grade Ⅲ carcinoma cells were respectively 73%, 20% and 67%, which were higher than those in gradeⅡ (13%, 0, 27%) and gradeⅠ (0) ones ( P
