Antineutrophil autoantibodies and their target antigens in lupus nephritis
- VernacularTitle:狼疮肾炎患者血清抗中性粒细胞抗体和靶抗原的研究
- Author:
Min CHEN
;
Minghui ZHAO
;
Youkang ZHANG
;
Haiyan WANG
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
Autoantibodies;
Antibodies,antineutrophil cytoplasmic;
Autoantigens
- From:
Chinese Journal of Rheumatology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the target antigens and their clinical association with antineutrophil autoantibodies in patients with lupus nephritis (LN).Methods Sera were collected from 92 renal biopsy proven LN patients.Normal neutrophils and white cells from patients with chronic granulocytic leukemia (CGL) were used as antigens in Western blot analysis to detect autoantibodies in the LN sera.Results ①Using neutrophils as antigens,two bands could be blotted:64 000 (33/92,35 9%)and 50 000 (13/92,14 1%).The prevalence of anti 64 000 autoantibody in patients with positive rheumatic factor was significantly higher than that in patients without (54 5% vs 18 8%, P
