QUANTITATIVE ANALYSES OF MORPHOLOGICAL CHANGES OF MYOCARDIAC CELLS ASSOCIATED WITH AGE IN RATS
- VernacularTitle:大鼠心肌细胞形态学增龄变化的定量研究
- Author:
Guotian YIN
;
Zhiku GUO
- Publication Type:Journal Article
- Keywords:
Myocardiac cells;
Image computer analyzer;
Morphology;
Change of age growth;
Rat
- From:
Acta Anatomica Sinica
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the regularities of myocardiac cells with age increasing. Methods 30 male rats were used in the experiment and divided into three groups:infant group (20\|25 day), young group (3\|5 month) and old group (13\|15 month). Routine paraffine sections were made for PTAH staining and data of cell area, nuclear area, ratio of nucleus to cytoplasm, nuclear ellipticity were measured by image computer analyzer. Results With advancing age:1\^ Cell area and nuclear area became larger; the ratio of nucleus to cytoplasm was declined; nuclear ellipticity turned high. 2\^The cell area of ventricular myocytes was bigger than that of atrial myocytes, the cell area of left atrial myocytes and left ventricular myocytes was bigger than that of right ones, and the cell area of interventricular septum was between that of right ventricular myocytes and left ones. 3\^ Myocardiac cells became thicker and longer; intercalated disc got distinct and complex.Conclusion The growth of nuclei seem to slower than that of myocardiac cells; the morphology of nucleus changes from round to ellipse; Round nucleus is one of important features of young cells; the cells in atrium is younger than that of ventricle.
