An experimental study of the effect of anetholtrithione on the prevention and treatment of non-alcoholic steatohepatitis
- VernacularTitle:茴三硫防治非酒精性脂肪性肝炎的实验研究
- Author:
Fei LIU
;
Lan ZHONG
;
Junchen WANG
- Publication Type:Journal Article
- Keywords:
Non-alcoholic steatohepatitis;
Anetholtrithione;
Rat
- From:
Chinese Journal of Digestion
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Non-alcoholic steatohepatitis(NASH) can progress to liver fibrosis and cirrhosis. Now there are few effective drugs to treat NASH. The aims of this study was to investigate the efficacy of anetholtrithione in the prevention and treatment of NASH in rats induced by high-fat diet. To evaluate the weight,liver index, serum aminotransferase activity and histological features. Methods Sixty SD male rats were divided into six groups. The controlled group(n=10) were fed with normal diet; the NASH model group(n=10)were fed with high-fat diet; the anetholtrithione prevention groups were fed with high-fat diet, and anetholtrithione.The rest rats were fed with high-fat diet, and twelve weeks later they were divided into three groups further. They were anetholtrithione treatment group, diet group and anetholtrithione +diet group. The anetholtrithione treatment group was fed with high-fat diet and anetholtrithione, diet group was fed with normal diet, and anetholtrithione+diet group was fed with normal diet and anetholtrithione. Sixteen weeks later, all rats were sacrificed. Results The anetholtrithione treatment group, diet group and anetholtrithione +diet group had a beneficial effect on lowing weight, liver index, serum aminotransferase activity. A significant improvement in some histological features such as steatosis and inflammation were also observed. Conclusion Anetholtrithione and diet therapy are effective in ameliorating NASH in rats.
