Effect of Naohuandan Capsule in Treating Mild and Moderate Cases of Vascular Dementia
- VernacularTitle:脑还丹胶囊治疗轻中度血管性痴呆临床观察
- Author:
Qihui HUANG
;
Zhaohui TAN
- Publication Type:Journal Article
- Keywords:
NAOHUANDAN CAPSULE/ther. use;
DEMENTIA, VASCULAR/TCD therapy;
ESTRADIOL/blood;
TESTOSTERONE/blood;
REINFORCING QI;
NOURISHING BLOOD;
EXPECTORANTS (TCD)/ther.use
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the therapeutic effect of Naohuandan Capsule (mainly composed of Radix Ginseng, Radix Rehmanniae Preparata,etc.) in treating mild and moderate cases of vascular dementia (VD).Forty five cases of VD, which are subjected to the diagnostic standard of American Association of Psychiatry (DSM Ⅳ), were randomly allocated to two groups for a 3-month treatment course. Group A (n=22) was treated with Naohuandan Capsule and Group B (n=23) with Naofukang Tablet. Therapeutic effect was evaluated by scoring of mini-mental state examination (MMSE) and activity of daily living (ADL) and serum levels of estradiol (E 2) and testosterone (T) were also observed.Scores of MMSE and ADL were increased, E 2 and T levels were elevated and the ratio of E 2/T was decreased in Group A(P0 05). [Conclusion]Naohuandan Capsule has a definite effect in preventing and treating VD and its mechanism may be related to the increase of E 2 and T levels, decrease of E 2/T ratio and the regulation of neuroendocrine function.
