Effect of Kaixin Capsule in Reconstructing the Collagen of Non-infarct Region of Left Ventricle in Rats after Myocardial Infarction
- VernacularTitle:开心胶囊对大鼠心梗后左室非梗塞区胶原改建的影响
- Author:
Yingchun ZHOU
;
Fengli ZHAO
;
Jinghe CHEN
;
Mi ZHU
- Publication Type:Journal Article
- Keywords:
KAIXIN CAPSULE/pharmacology;
MYOCARDIAL INFARCTION/TCD therapy;
MYOCARDIUM/drug effects;
COLLAGEN/drug effects;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To explore the effect of Kaixin Capsule (KC, composed of Radix Panacis Quinquefolii, Radix Astragali, Radix Ophiopogonis, Rhizoma Chuanxiong,Rhizoma Cyperi, etc.) in reconstructing the collagen of non infarct region of left ventricle in rats after myocardial infarction (MI) and to study its mechanism.Seventy rats were allocated to mimic operation group (Group Ⅰ), model group (Group Ⅱ), high dosage KC group (Group Ⅲ), low dosage KC group (Group Ⅳ) and positive control group (Group Ⅴ). Rat models of left ventricle reconstruction were established by the ligation of the main stem of left coronary artery. Three days after modeling, the rats were treated with KC for eight weeks. And then the total collagen content in the myocardium of non infarct region and angiotensin Ⅱ (AngⅡ) and aldosterone (ALD) levels in blood and myocardium were measured by oxyproline hydroxyproline method and radioimmunoassay. The total collagen content was higher in Group Ⅱ than that in Group Ⅰ (P0 05) . [Conclusion]KC can inhibit the production of collagen and increase myocardial compliance and its mechanism may be involved in the regulation of rennin angiotensin aldosterone system.
