In-vitro Protective Effects of Baoganning on Injury of Liver Cells Induced by Hydrogen Peroxide in Rats
- VernacularTitle:保肝宁对过氧化氢损伤大鼠肝细胞的保护作用
- Author:
Jinjun ZHAO
;
Zhiping L
;
Yonggang LIU
;
Xuf ZHANG
- Publication Type:Journal Article
- Keywords:
BAOGANNING/therapeutic use;
LIVER CELLS/drug effects;
SUPEROXIDE DISMUTASE/analysis;
NITRIC OXIDE /analysis;
MALONDIALDEHYDE/analysis;
GLUTAMIC PYRUVIC TRANSAMINASE/analysis
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects of Baoganning on injury of liver cells induced by hydrogen peroxide (H 2O 2) in rats.Rat models of injury of liver cells were induced by H 2O 2 at final concentration of 2 mmol/L. Six kinds of suspension of isolated rat liver cells were prepared according to the addition of serum. They were group A ( blank control), group B (H 2O 2 model), group C (normal control), group D (vitamin E), group E (low dosage of Baoganning) and group F (high dosage of Baoganning). Superoxide dismutase (SOD) activity, nitric oxide (NO) and malonyl dialdehyde (MDA) contents and glutamic pyruvic transaminase (ALT) level were detected.SOD activity and NO and MDA contents were increased and ALT level was decreased in Baoganning groups.[Conclusion]Baoganning exerts a protective effect on injury of liver cells induced by H 2O 2 in rats.
