Studies on biopharmacy of ultra-fine particles of Atractylodes lancea, Phellodendron chinense and pill composed of mentioned two herbsⅡ. Study on dissolution rate in vitro of ultra-fine ERMTAO PILL
- VernacularTitle:苍术、黄柏及二妙丸超细微粉的生物药剂学的研究 Ⅱ.超细粉二妙丸的体外溶出度研究
- Author:
Hongyu YUAN
;
Fang HUANG
;
Liwei GUO
;
Wanqin JIN
;
Taoshi LIU
- Publication Type:Journal Article
- Keywords:
ERMIAO PILL;
dissolution rate;
ultra-fine grinding
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To investigate the effects of ultra-fine powder technique and granularity of pellets on dissolution rate in vitro. Methods The dissolution rate of ultra-fine ERMIAO PILL with different granule diameters in vitro was measured and compared with the index of berberine by UV spectro-photometry. Results The dissolution parameters T 50 and T d of four kinds of ultra-fine ERMIAO PILL are 61.60, 19.48, 17.84, 8.97 min and 102.3, 33.29, 26.98, 14.77 min, respectively. Those of general powder ERMIAO PILL with granule diameter of 2.4 mm are 89.61 and 155.68 min. Conclusion The dissolution rate of ultra-fine powder is quicker than that of general powder, and the rate increases with the granularity of PILL decreasing.
