Studies on pharmacokinetics of Musk Protecting Heart Pellets with pH-dependent gradient-release and Musk Protecting Heart Pills
- VernacularTitle:麝香保心pH依赖型梯度释药微丸和麝香保心丸的药效动力学
- Author:
Hongtao SONG
;
Tao GUO
;
Ruhua ZHANG
;
Haiyang HU
;
Xian LI
;
Xianyin CHEN
- Publication Type:Journal Article
- Keywords:
Musk Protecting Heart Pellets with pH-dependent gradient-release (MPHP-pH);
Musk Protecting Heart Pills (MPHP);
cardiac muscle nutritional blood flow;
pharmacokinetics
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To investigate the pharmacokinetic parameters of Musk Protecting Heart Pellets with pH-dependent gradient-release (MPHP-pH) and Musk Protecting Heart Pills (MPHP). Methods The cardiac muscle nutritional blood flow in rat was measured as effective index. Results It was one-compartment model when the rat was ig MPHP. The minimal effecting dose was 0.54 mg/kg, the present half-life, the elimination half-life, medicinal effect and the peak time of effective action were 0.53, 1.21, 3.48 and 1.13 h, respectively. The absorption half-life, elimination half-life and peak time of effective dose were 0.23, 1.47 and 0.88 h, respectively. Statistical moment analysis showed that the mean residence time mean residence time (MRT) of effective action were 5.05 h for MPHP-pH and 2.33 h for MPHP, the MRT of effective dose were 7.70 h for MPHP-pH and 3.21 h for MPHP. The relative bioavailability of effective dose for MPHP-pH was 104.03%. Conclusion MPHP has the characteristics of fast absorption, fast eliminationand short effective action time. Whereas MPHP-pH has the characteristics of fast absorption, protonged and relaxed effective action compared with MPHP.
