Induction of human tumor cell apoptosis by sodium artesunate and its molecular mechanism
- VernacularTitle:青蒿酯钠诱导人肿瘤细胞凋亡及其分子机制的探讨
- Author:
Xiaoping YANG
;
Xing ZHANG
- Publication Type:Journal Article
- Keywords:
sodium artesunate (SA);
apoptosis;
gene
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the apoptosis induced by sodium artesunate (SA) in human liver cancer cells and its molecular mechanism. Methods Induction of the apoptosis was analyzed by fluorescent microscope, transmission electron micrograph and flow lytometry based on drug treated BEL-7402. Expressions of p53, p21 and bc1-2 were determined by Western blot. Results The expression level of p53 and p21 had no change remarkbly, but the expression level of bc1-2 was reduced compared to that of the control group after the human liver cancer cells were treated by SA. Conclusion The apoptosis in human liver cancer cells (BEL-7402) may be induced by SA, the molecular mechanism of apoptosis may be p53-independent, that is no relative to p53 and p21. Otherwise, it is relative to bc1-2 down-regulation.
