Study of relationship between T helper cell type-1 and type-2 cytokines and intrahepatic cholestasis of pregnancy
- VernacularTitle:辅助性T淋巴细胞亚型与妊娠期肝内胆汁淤积症发病的关系
- Author:
Bing PENG
;
Shuyun LIU
- Publication Type:Journal Article
- Keywords:
Pregnancy complications;
Cholestasis, intrahepatic;
T-lymphocyte subsets;
Cytokines
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of T helper cell type-1(TH 1) cytokines [interferon-? (IFN-?), tumor necrosis factor-a (TNF-?)] and T helper cell type-2(TH 2) cytokines [interleukin-4 (IL-4)] on pathogenesis of intrahepatic cholestasis of pregnancy (ICP). Methods The peripheral blood mononuclear cells (PBMC) from 20 cases of ICP patients (study group) and 20 cases of normal pregnant women (control group) were cultured with photohemglutinin stimulation. TNF-?, IFN-? and IL-4 were determined in the supernatant by enzyme- linked-immunoassay. Results (1) In supernatants of cultured PHA induced PBMC, the levels of IFN-? and TNF-? of study group were (639?156) ng/L and (1 021?231) ng/L, which were significantly higher than those of control group, (464?147)ng/L and (728?175) ng/L( P
