Assessment of efficacy of pinaverium bromide in treatment of irritable bowel syndrome and its effect on visceral motility and sensitivity
- VernacularTitle:匹维溴铵治疗肠易激综合征的临床疗效及改变肛门直肠动力和内脏敏感性研究
- Author:
Lixing ZHAN
;
Zhaoshen LI
;
Duowu ZOU
- Publication Type:Journal Article
- Keywords:
Pinaverium bromide;
Irritable bowel syndrome;
Anorectal;
Motility;
Sensitivity
- From:
Chinese Journal of Digestion
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effects of pinaverium bromide on irritable bowel syndrome (IBS), and to study its effect on rectal visceral perception and anorectal manometry. Methods Eighty four patients with IBS received pinaverium bromide 50 mg t.i.d for 2 weeks. The score of symptoms was assessed before, after one week and 2 weeks of threatment. Rectal visceral perception thresholds, rectal compliance and anorectal manometry were measured before and after administration of pinaverium bromide. Results Pinaverium bromide 150 mg/d significantly improved the score of abdominal pain, abdominal distension and mucus stool(2.13?0.36 vs 1.28?0.35,2.49?0.73 vs 1.35?0.17,1.03?0.27 vs 0.43?0.12, P
