Association of MICA gene exon 2～4 polymorphism with seronegative spondylarthropathies
- VernacularTitle:MICA基因第2、3和4外显子多态性与血清阴性脊柱关节病关联研究
- Author:
Weijuan GONG
;
Lian FAN
;
Jueqin YANG
;
Fangjuan YAO
;
Lingdi XU
- Publication Type:Journal Article
- Keywords:
HLA B27 antigen;
Linkage disequilibrium;
Spinal diseases;
Genes,MICA
- From:
Chinese Journal of Rheumatology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether MICA gene exon 2,3 and 4 polymorphism is associated with seronegative spondylarthropathies (SpA) or not in Chinese Han population.Methods All 199 B27 positive patients with SpA and 183 randomly ethnically matched healthy controls,and 12 B27 positive controls were enrolled to detect the MICA genotype from its exons 2,3 and 4 by using PCR SSOP method in Shanghai area.Results The MICA007 allele frequency was significantly more in the patient group (18 0%) than in the randomly healthy control group (6 6%) (RR=3 04, P =0 000 045).However,the MICA007 allele frequency was not significantly higher in the B27 positive patient group than in the B27 positive control group.Conclusion The MICA007 allele itself may not be the real disease susceptibility gene involved in the development of ankylosing spondylitis.The increased frequency of MICA007 allele is supposed to be due to a strong linkage disequilibrium between MICA and HLA B genes.
