An association between gene polymorphism of tumor necrosis factor ? and systemic lupus erythematosus
- VernacularTitle:肿瘤坏死因子-?基因多态与系统性红斑狼疮关系研究
- Author:
Chaowei FU
;
Fumin SHEN
;
Pengsheng NI
;
Wei MENG
;
Feng JIANG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Lymphotoxin;
Polymorphism (genetics)
- From:
Chinese Journal of Rheumatology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To make sure whether there is any association between genetic polymorphism of tumor necrosis factor (TNF) ? and systemic lupus erythematosus (SLE).Method PCR RFLP was used.A population based and family based study was carried out in 99 SLE patients,116 health controls and 12 families.Results The TNF ?2 allele frequency of SLE patients was significantly different from that of controls ( P
