RELATIONSHIPS BETWEEN THE EXPRESSION OF cNOS mRNA IN GASTRIC CARCINOMAS AND THE INVASION,METASTASIS AND PROGNOSIS
- VernacularTitle:组成型一氧化氮合酶的表达与胃癌的侵袭转移和预后的关系
- Author:
Jianyin LIN
;
Sheng ZHANG
;
Li LI
;
Hu LIN
- Publication Type:Journal Article
- Keywords:
Gastric neoplasms;
cNOS mRNA;
Invasion;
Metastasis;
Prognosis
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate relationships between the expression of cNOS mRNA and invasion and metastasis and prognosis in primary gastric carcinomas. Methods In situ hybridization was used to determine the expression of cNOS mRNA in 119 gastric cancer and 82 follow-up data were analyzed to obtain survival figures. Results In gastric carcinoma specimens,the expression of cNOS mRNA can be observed in the tumor cells,endothelial cells and mononuclear phagocytes;the poorer the carcinoma differentiation,the higher the positive rate of cNOS mRNA in tumor cells and endothelial cells;the expression of cNOS mRNA in tumor cells and endothelial cells reveals a significant positive correlation to the depth of invasion,lymph node metastasis and TNM stage;the patient with positive expression of cNOS mRNA in endothelial cells has a poor prognosis;the expression of cNOS mRNA in mononuclear phagocytes is not related to histopathologic type,the depth of invasion,lymph node metastasis and TNM stage.Conclusion In gastric carcinoma,the expression of cNOS mRNA in tumor cells and endothelial cells might be realted to potential of invasion,metastasis,and the patient with cNOS mRNA positive expression in endothelial cells would have a poor prognosis.
