The effects of ventilation with high density oxygen on the strength of gastrointestinal anastomosis.
10.4174/astr.2015.89.1.17
- Author:
Tevfik EKER
1
;
Volkan GENC
;
Yusuf SEVIM
;
Ozge CUMAOGULLARI
;
Menekse OZCELIK
;
Akin Firat KOCAAY
;
Cemal Ozben ENSARI
;
Ozge Tugce PASAOGLU
Author Information
1. Department of General Surgery, Ankara University Medical School, Ankara, Turkey. volkangenc77@yahoo.com
- Publication Type:Original Article
- Keywords:
Anastomosis;
Wistar rats;
Oxygen
- MeSH:
Animals;
Humans;
Hydroxyproline;
Male;
Oxygen*;
Rats;
Rats, Wistar;
Ventilation*
- From:Annals of Surgical Treatment and Research
2015;89(1):17-22
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of our study is to evaluate the effects of administration of perioperative supplemental oxygen on anastomoses. METHODS: Forty male Wistar albino rats were used in the study and randomized into 4 groups. Ischemia-reperfusion models were built in groups 3 and 4. Jejunojejunostomy was performed in all rats and assigned to an oxygen/nitrous oxide mixture with a fraction of inspired oxygen of 30% in groups 1 and 3 and 80% in groups 2 and 4. The measurements of perianastomotic tissue oxygen pressure, bursting pressure, level of hydroxyproline were evaluated and compared in all groups. RESULTS: The perianastomotic tissue oxygen pressures, bursting pressures and levels of hydroxyproline were identified as significantly high in groups 2 and 4, administered a fraction of inspired oxygen of 80%, compared to groups 1 and 3, administered a fraction of inspired oxygen of 30%. CONCLUSION: Perioperative supplemental oxygen contributes positively to the anastomotic healing.
